Ghussen F, Nagel K, Groth W
Dtsch Med Wochenschr. 1981 Nov 27;106(48):1612-5. doi: 10.1055/s-2008-1070564.
From December 1978 to February 1981 91 regional hyperthermic perfusions with melphalan (1.0 or 1.5 mg/kg body weight) were performed in 87 patients with malignant melanoma of the extremities. During a one-hour perfusion with whole blood at an intramuscular temperature of 42 degrees C the flow rate was 264 +/- 62 ml/min in the upper and 495 +/- 42 ml/min in the lower limb. Apart from one intima dissection there were no serious intraoperative complications. Postoperatively one female patient died on the 19th day from acute right heart failure with severe bone marrow suppression. In six patients intransigent metastases appeared after an average of six months. One patient developed lung metastases 7 months postoperatively from which he died. Seventy-nine patients remained free of tumour during the observation period.
1978年12月至1981年2月，对87例四肢恶性黑色素瘤患者进行了91次美法仑（1.0或1.5mg/kg体重）区域热灌注治疗。在肌肉温度为42℃的全血灌注1小时过程中，上肢血流量为264±62ml/min，下肢为495±42ml/min。除1例内膜剥离外，无严重术中并发症。术后1例女性患者于第19天死于急性右心衰竭伴严重骨髓抑制。6例患者平均6个月后出现顽固性转移。1例患者术后7个月发生肺转移并死亡。79例患者在观察期内无肿瘤复发。
