Nagy L
Eur J Respir Dis. 1981 Jun;62(3):198-203.
Neutrophil chemotactic activity of the serum, leukocyte count and total eosinophil count were determined before and after bronchial provocation with inhalation of house dust or acetylcholine. Airway parameters were determined by whole-body plethysmography. The airway conductance started to return to normal between 20 and 60 min after provocation as did the chemotactic activity. The largest increase of serum neutrophil chemotactic activity was measured 20 min after challenge with house dust, and the activity did not return to the initial value within 24 h, unlike specific airway conductance which was normalized at 24 h. No alteration of the leukocyte count was found. A significant decrease of the total eosinophil count was observed at 60 min, then a 1.5-fold increase was seen at 24 h. Positive correlation was found between the eosinophil count and the lung function. A putative pathophysiological role of the neutrophil chemotactic factor of mast cell origin in bronchial asthma is suggested.
在吸入屋尘或乙酰胆碱进行支气管激发前后，测定血清中性粒细胞趋化活性、白细胞计数和嗜酸性粒细胞总数。通过全身体积描记法测定气道参数。激发后20至60分钟，气道传导率开始恢复正常，趋化活性也如此。用屋尘激发后20分钟测得血清中性粒细胞趋化活性增加最大，且该活性在24小时内未恢复至初始值，这与24小时恢复正常的比气道传导率不同。未发现白细胞计数有改变。在60分钟时观察到嗜酸性粒细胞总数显著减少，然后在24小时时增加了1.5倍。发现嗜酸性粒细胞计数与肺功能之间呈正相关。提示肥大细胞来源的中性粒细胞趋化因子在支气管哮喘中可能具有病理生理作用。
