Tsumoto T, Freeman R D
Exp Brain Res. 1981;44(3):347-51. doi: 10.1007/BF00236575.
We have monitored extracellularly individual neurons in the striate cortex of 4-week-old unparalyzed kittens with the aim of changing the ocular dominance of these cells during recording. To do this, we elicited conjugate eye movements using a bipolar stimulating electrode positioned in the internal medullary lamina (IML) of the thalamus. During electrical stimulation of this region, one eye was occluded and the other was visually activated with optimal stimuli. Receptive fields were studied subjectively and objectively and relative response strengths were assessed. Of 42 cells studied in detail, 62% underwent changes on ocular dominance following conditioning periods of, generally, 15-20 min. Control experiments suggest that this plasticity is: age-related; requires both visual stimulation and activation of pathways associated with eye movement; and does not appear to be caused solely by increased arousal levels.
我们在4周龄未瘫痪小猫的纹状皮质中对单个神经元进行了细胞外监测，目的是在记录过程中改变这些细胞的眼优势。为此，我们使用位于丘脑内侧髓板（IML）的双极刺激电极诱发共轭眼球运动。在对该区域进行电刺激时，一只眼睛被遮挡，另一只眼睛用最佳刺激进行视觉激活。对感受野进行了主观和客观研究，并评估了相对反应强度。在详细研究的42个细胞中，一般经过15 - 20分钟的条件训练后，62%的细胞眼优势发生了变化。对照实验表明，这种可塑性与年龄有关；需要视觉刺激和与眼球运动相关的通路激活；而且似乎并非仅由觉醒水平的提高引起。
