Patton D L, Halbert S A
Fertil Steril. 1981 Dec;36(6):808-13. doi: 10.1016/s0015-0282(16)45930-3.
Long-term hydrosalpinges were mechanically induced in rabbits by ligation of the fimbriated end of the oviduct. The structure and function of these model hydrosalpinges were studied 28 to 52 weeks following ligation. This procedure caused a nonpurulent, clear serous fluid to accumulate within the lumen of the ampulla, which resulted in dilatation of the ampulla and thinning of the tubal wall. The intraluminal mucosal folds were attenuated in the expanded regions; however, normal ciliation was predominant throughout the endosalpinx. Two rabbits, one with a single distal tubal ligation and the other with double ampullary ligation, showed abnormal epithelium with distinct patches of flattened polygon-shaped, nonciliated cells. In vivo and in vitro observations of luminal transport of surrogate ova in cumulus showed that ciliary transport was not affected by the long-term gross distension of the ampullae. The authors conclude that long-term tubal dilatation by itself does not alter tubal morphology sufficiently to impair ovum transport function in the oviductal ampulla.
通过结扎输卵管伞端在兔体内机械诱导形成长期输卵管积水。在结扎后28至52周对这些模型输卵管积水的结构和功能进行了研究。该操作导致壶腹部管腔内积聚非脓性、清澈的浆液性液体，进而导致壶腹部扩张和输卵管壁变薄。扩张区域的管腔内黏膜皱襞变细；然而，整个输卵管内膜中正常纤毛占主导。两只兔子，一只进行了单侧输卵管远端结扎，另一只进行了双侧壶腹部结扎，其上皮出现异常，有明显的扁平多边形、无纤毛细胞斑块。对卵丘中替代卵子的管腔运输进行的体内和体外观察表明，纤毛运输不受壶腹部长期严重扩张的影响。作者得出结论，长期的输卵管扩张本身并不会充分改变输卵管形态，从而损害输卵管壶腹部的卵子运输功能。
