Naito M, Naito Y, Ito A
Gan. 1981 Aug;72(4):569-77.
The effect of age at treatment on the incidence and location of neurogenic tumors induced by N-ethyl-N-nitrosourea (ENU) was investigated in 232 Wistar rats of both sexes. Rats were given 40 ng/kg of ENU on the 16th day of gestation (group I), on the day of birth (group II), and on the 1st week (group III), 2nd week (group IV), 3rd week (group V) and 4th week (group VI) after birth. Up to 6 months of observation, the brain consistently showed the highest susceptibility ranging from group I (93%) to group VI (36%), followed by the spinal cord (group I, 34%; group II, 64%; group III, 43%). However, the trigeminal nerve was only susceptible in group I (27%) and group II (36%) and the spinal root was susceptible exclusively in group II (46%). Most of the tumors obtained were oligodendrogliomas or mixed gliomas. Glioependymomas of the spinal cord were predominant only in group II. The temporal and paraventricular regions and hippocampus were the preferred sites of brain tumors in group I and II, but in groups III and IV frontal tumors were predominant. Mesenchymal tumors of the kidney were also induced, mainly in groups III (16%) and IV (16%).
在232只雌雄Wistar大鼠中研究了治疗时的年龄对N-乙基-N-亚硝基脲（ENU）诱导的神经源性肿瘤的发生率和位置的影响。在妊娠第16天（I组）、出生当天（II组）以及出生后第1周（III组）、第2周（IV组）、第3周（V组）和第4周（VI组）给大鼠注射40 ng/kg的ENU。在长达6个月的观察期内，大脑始终表现出最高的易感性，范围从I组（93%）到VI组（36%），其次是脊髓（I组，34%；II组，64%；III组，43%）。然而，三叉神经仅在I组（27%）和II组（36%）易感，脊髓神经根仅在II组易感（46%）。获得的大多数肿瘤为少突胶质细胞瘤或混合性胶质瘤。脊髓胶质室管膜瘤仅在II组占主导。颞叶和脑室旁区域以及海马是I组和II组脑肿瘤的首选部位，但在III组和IV组中额叶肿瘤占主导。肾脏的间充质肿瘤也被诱导产生，主要在III组（16%）和IV组（16%）。
