Miehle W, Rehs E L, Zollner E
Fortschr Med. 1981 Nov 26;99(44):1830-3.
9 patients with rheumatoid arthritis and one with activated gonarthrosis were treated by means of application of Amuno ointment to one knee in a dosage of 3 X 5 cm ribbon of ointment, rubbed in on an area of approximately 200 cm2, over a period of 3 days. After this interval in 8 patients the knee-joints not treated with ointment were punctured, and synovial fluid was won. In all 10 cases serum level determinations were carried out. The obtained average values in serum ranged from 114.4 - 134.3 ng/ml, the average value found in the synovial fluid was ascertained at 235.6 ng/ml. Although this report is presenting only intermediate results these may nevertheless serve as evidence for a systemic effect of Amuno ointment at the synovium.
9例类风湿性关节炎患者和1例活动性膝关节病患者接受了治疗，方法是在一侧膝关节涂抹Amuno软膏，用量为3×5厘米带状软膏，在约200平方厘米的区域涂抹并揉搓，持续3天。在此间隔后，对8例患者未涂抹软膏的膝关节进行穿刺，获取滑液。对所有10例患者都进行了血清水平测定。血清中获得的平均值在114.4 - 134.3纳克/毫升之间，滑液中的平均值确定为235.6纳克/毫升。尽管本报告仅呈现中期结果，但这些结果仍可作为Amuno软膏对滑膜产生全身作用的证据。
