Ching M
Horm Res. 1981;14(4):234-42. doi: 10.1159/000179393.
Even though growth hormone was reported to play a role in mammalian calorigenesis, few studies have examined its effect on thyroid function. Consequently, the modulatory effect of bovine growth hormone (BGH) on thyroid incorporation of 131I was studied in hypophysectomized (H) rats. Not surprisingly, H recipients fed a low iodine diet consistently displayed greater thyroidal uptakes of radioactive iodine than recipients given regular diets. Furthermore, thyroid radioactive counts increased predictably in direct proportion to the quantity of bovine thyrotropin administered. Larger doses of BGH suppressed the thyroidal uptake of 131I whereas smaller doses either had no effect or enhanced thyroidal activity. Thus, these results affirm that radiolabelled and non-radiolabelled iodine compete in thyroid metabolic processes and furthermore demonstrate that high doses of BGH inhibit thyroid activity.
尽管有报道称生长激素在哺乳动物的产热过程中发挥作用，但很少有研究考察其对甲状腺功能的影响。因此，在垂体切除的（H）大鼠中研究了牛生长激素（BGH）对甲状腺摄取¹³¹I的调节作用。不出所料，喂食低碘饮食的H受体大鼠甲状腺对放射性碘的摄取量始终高于喂食常规饮食的受体大鼠。此外，甲状腺放射性计数与所给予的牛促甲状腺素的量成正比增加。大剂量的BGH抑制了甲状腺对¹³¹I的摄取，而小剂量的BGH要么没有影响，要么增强了甲状腺活性。因此，这些结果证实了放射性标记和非放射性标记的碘在甲状腺代谢过程中相互竞争，并且进一步证明高剂量的BGH会抑制甲状腺活性。
