淀粉样变性与系统性红斑狼疮。

Amyloidosis and systemic lupus erythematosus.

作者信息

Sweet J, Bear R A, Lang A P

出版信息

Hum Pathol. 1981 Sep;12(9):853-6. doi: 10.1016/s0046-8177(81)80092-5.

Abstract

A 59 year old man with systemic lupus erythematosus developed proteinuria and renal insufficiency. Renal biopsy revealed both crescentic glomerulonephritis and amyloid in glomeruli and blood vessels. The amyloid was characterized as secondary because of its sensitivity to potassium permanganate pretreatment of Congo red stained sections. Amyloidosis is very uncommon in systemic lupus erythematosus but may be a cause of steroid unresponsive proteinuria and renal insufficiency.

摘要

一名59岁的系统性红斑狼疮男性患者出现蛋白尿和肾功能不全。肾活检显示既有新月体性肾小球肾炎，又有肾小球和血管内的淀粉样物质。由于刚果红染色切片经高锰酸钾预处理后其淀粉样物质具有敏感性，因此该淀粉样物质被归类为继发性。淀粉样变性在系统性红斑狼疮中非常罕见，但可能是类固醇抵抗性蛋白尿和肾功能不全的一个原因。