Nuttall A L, Hultcrantz E, Lawrence M
Hear Res. 1981 Nov;5(2-3):285-93. doi: 10.1016/0378-5955(81)90052-6.
The effect of loud sound on the perilymphatic oxygen tension was studied in anesthetized guinea pigs. Pure tone (4 kHz) and broad-band noise were given at 85-130 dB SPL for 3-8 min. No effects were seen either in the animals exposed to pure tone or in the animals exposed to 85 dB broad-band noise. In the animals exposed to noise at 130 dB SPL both increases and decreases of perilymphatic oxygen were measured but the changes were only of about 12% or less. The response to anoxia was normal. In animals with hypotension ( less than 8 kPa) the perilymphatic PO2 fluctuated with the blood pressure. When the sound was delivered directly into the opened bulla the measured PO2 dropped immediately but was found to be caused by the cooling effect of an air current produced by the noise. Flushing the opened bulla with nitrogen, air or oxygen caused the same temperature-induced drop of measured PO2. The results and the artifacts are discussed.
在麻醉的豚鼠身上研究了大声响对外淋巴氧张力的影响。以85 - 130 dB SPL的强度给予纯音（4 kHz）和宽带噪声，持续3 - 8分钟。暴露于纯音的动物和暴露于85 dB宽带噪声的动物均未出现影响。在暴露于130 dB SPL噪声的动物中，测量到外淋巴氧既有增加也有减少，但变化仅约12%或更小。对缺氧的反应正常。在低血压（低于8 kPa）的动物中，外淋巴PO2随血压波动。当声音直接传入打开的鼓泡时，测量到的PO2立即下降，但发现这是由噪声产生的气流的冷却效应引起的。用氮气、空气或氧气冲洗打开的鼓泡会导致相同的温度诱导的测量PO2下降。对结果和假象进行了讨论。
