Linden D C, Guillery R W, Cucchiaro J
J Comp Neurol. 1981 Dec 1;203(2):189-211. doi: 10.1002/cne.902030204.
The anterograde transport of 3H proline and of horseradish peroxidase has been used to study the retinogeniculate pathway in normal adult ferrets and in young ferrets during postnatal development. the lateral geniculate nucleus in adults shows a characteristic "carnivore" pattern, with layers A, A1, C, C1, C2, and C3, and a medial interlaminar nucleus recognizable either cytoarchitectonically or on the basis ofth retinogeniculate innervation. In addition, there is a well-defined, rather large perigeniculate nucleus. At birth the lateral geniculate nucleus is unlaminated and essentially all parts are reached by afferents from both eyes. The crossed component is by far the larger. It extends from the optic tract medially well into the perigeniculate field, in contrast to the uncrossed component which barely reaches the perigeniculate field. During the first 3 postnatal days the uncrossed fibers restrict their arbors to a small posterior and medial region, the precursor of the biocular segment of the nucleus. The crossed fibers gradually retreat from the region within which the uncrossed fibers have concentrated. Between the fourth and eighth postnatal days the field occupied by the ipsilateral component expands again to form a major focus that will define lamina A1 and a minor focus that will define C1. At this stage the crossed and the uncrossed fibers overlap at the borders of lamina A1 and the whole region of lamina C1 is also occupied by arbors of the crossed component. The perigeniculate field becomes clearly distinguishable from the lateral geniculate nucleus and the medial interlaminar nucleus is becoming clearly recognizable between days 3 and 8. Between days 8 and 15 the cytoarchitectonic borders between layers A and A1 become clearly defined, but the retinogeniculate axons from each eye still extend across this border. These axons retreat into their appropriate lamina after the 15th postnatal day an the nucleus reaches its essentially adult structure by about the fourth postnatal week. Segregation of retinofugal axons in the C layers occurs after segregation in the A layers, but many of the cells within the C layers show signs of cytological maturity earlier than those of the A layers. The nucleus undergoes a series of migrations and changes of shape as the ipsilateral and contralateral components become segregated. Whereas in teh newborn the nucleus is roughly comma-shaped and on the lateral aspect of the dorsal thalamus, in the adult it is "L"-shaped and mainly on the posterior aspect of the dorsal thalamus.
利用³H脯氨酸和辣根过氧化物酶的顺行运输来研究正常成年雪貂以及幼龄雪貂出生后发育过程中的视网膜膝状体通路。成年雪貂的外侧膝状体核呈现出典型的“食肉动物”模式，有A、A1、C、C1、C2和C3层，以及一个在细胞构筑学上或基于视网膜膝状体神经支配可识别的内侧层间核。此外，还有一个界限分明、相当大的外侧膝状体旁核。出生时，外侧膝状体核未分层，基本上所有部分都有来自双眼的传入纤维到达。交叉成分远大于未交叉成分。它从视束内侧一直延伸到外侧膝状体旁区域，而未交叉成分几乎未到达外侧膝状体旁区域。在出生后的头3天里，未交叉纤维将其分支限制在一个小的后部和内侧区域，即该核双眼段的前身。交叉纤维逐渐从未交叉纤维集中的区域退缩。在出生后的第4天至第8天之间，同侧成分占据的区域再次扩大，形成一个将界定A1层的主要焦点和一个将界定C1层的次要焦点。在这个阶段，交叉纤维和未交叉纤维在A1层边界处重叠，C1层的整个区域也被交叉成分的分支占据。外侧膝状体旁区域在第3天至第8天之间变得明显可与外侧膝状体核区分开来，内侧层间核也变得清晰可辨。在第8天至第15天之间，A层和A1层之间细胞构筑学边界变得清晰界定，但来自每只眼睛的视网膜膝状体轴突仍延伸穿过这个边界。这些轴突在出生后第15天之后退缩到其相应的层中，该核在出生后约第四周达到其基本的成年结构。C层中视网膜传出轴突的分离发生在A层分离之后，但C层内的许多细胞比A层细胞表现出更早的细胞学成熟迹象。随着同侧和对侧成分的分离，该核经历了一系列迁移和形状变化。在新生儿中，该核大致呈逗号形，位于背侧丘脑的外侧，而在成年人中，它呈“L”形，主要位于背侧丘脑的后部。
