Murine arylsulfatase B: regulation of As-1 expression in different tissues.

The proportions of arylsulfatases A, B and B' differ markedly among various murine tissues. Although arylsulfatase B' may be a derivative of arylsulfatase B, their respective activities appeared to vary independently in the five murine tissues investigated. As-1, the apparent structural locus for murine arylsulfatase B, is expressed in brain, liver, kidney, lung, and spleen. Heat-stable arylsulfatase B is inherited as an autosomal incomplete dominant in most tissues. Current evidence suggests the existence of a regulatory element with cis-dominant effects that is situated near As-1 and is expressed in these tissues. However, control of liver arylsulfatase B is subject to more complex control and may involve participation of several genes, some of which are unlinked to As-1.