MacMillan G J
J Embryol Exp Morphol. 1981 Aug;64:333-41.
Genes which affect pigment elaboration may do so by autonomous action within the developing pigment cells or by way of tissue interactions leading to pigment cell differentiation. The site of action of the periodic albinism (ap) gene was investigated by substituting presumptive neural ectoderm of gastrulae of one genotype with uncommitted ectoderm of different genotype. Retinal pigment cells and melanophores arising from such grafts were found to differentiate according to their own genotype in spite of having spent their entire developmental history in tissues of different genotype. This finding demonstrates autonomous action of the ap gene within pigment cell derivatives and does not support recent proposals that the ap gene is involved in inductive interactions leading to melanogenesis. Experiments in which portions of presumptive dorsal mesoderm, implanted in gastrulae of different genotype, induced secondary pigment cells of host phenotype further support the proposal that the ap effect on pigment cells is not mediated by inductive interactions.
影响色素形成的基因可能通过在发育中的色素细胞内自主发挥作用，或者通过导致色素细胞分化的组织相互作用来实现。通过用不同基因型的未分化外胚层替代一种基因型原肠胚的假定神经外胚层，研究了周期性白化病（ap）基因的作用位点。尽管这些移植产生的视网膜色素细胞和黑素细胞在不同基因型的组织中度过了它们的整个发育历程，但发现它们根据自身的基因型进行分化。这一发现证明了ap基因在色素细胞衍生物中的自主作用，并不支持最近关于ap基因参与导致黑色素生成的诱导相互作用的提议。将假定的背侧中胚层部分植入不同基因型原肠胚中，诱导出宿主表型的次级色素细胞的实验，进一步支持了ap对色素细胞的影响不是由诱导相互作用介导的这一提议。
