Golubeva O N, Zviadadze K G, Lopashov G V
Ontogenez. 1985 Jul-Aug;16(4):389-97.
The inducing influence of adult eye tissues on the early gastrula ectoderm was studied in vitro. Both retina and pigment epithelium induced in the early gastrula ectoderm similar spectra of cell types, including nervous tissue, retina, pigment epithelium, lentoids, ectomesenchyme, and melanophores. It is suggested that the correspondence of these cell types with those arising at a spontaneous transdifferentiation of the isolated retina and pigment epithelium cells in vitro or at the induction of the early gastrula ectoderma by archencephalic endomesoderm during the normal development can be accounted for by that in these eye cells molecular determinants appeared as a result of induction and maintaina the stability of their differentiation and their potencies to transdifferentiation in vitro being reproduced during the lifetime of these cells.
在体外研究了成年眼组织对早期原肠胚外胚层的诱导影响。视网膜和色素上皮均能在早期原肠胚外胚层中诱导出相似的细胞类型谱,包括神经组织、视网膜、色素上皮、晶状体、外间充质和黑素细胞。有人提出,这些细胞类型与体外分离的视网膜和色素上皮细胞自发转分化时或正常发育过程中脑前内胚层诱导早期原肠胚外胚层时产生的细胞类型相对应,这可以解释为在这些眼细胞中,分子决定因素是诱导的结果,并维持其分化稳定性以及在这些细胞的生命周期中体外再现转分化能力。