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成年猫慢性皮质传入神经阻滞术后外侧膝状核中的有髓神经细胞体和树突

Myelinated perikarya and dendrites in lateral geniculate nucleus of adult cat following chronic cortical deafferentation.

作者信息

Hámori J, Silakov V L

出版信息

J Neurocytol. 1981 Oct;10(5):879-88. doi: 10.1007/BF01262659.

DOI:10.1007/BF01262659
PMID:7310480
Abstract

Chronic (one year) cortical deafferentation resulted in the appearance of myelinated neuronal perikarya and dendritic processes in the lateral geniculate nucleus (LGN) of the cat. Four per cent of all nerve cell bodies, both large and small, were observed to be covered partially or totally by compact myelin sheath. The myelination of the dendrites was confined to the most proximal portion of the processes. A comparison of the fine structural features of the myelinated cell bodies and dendrites with those from intact LGN indicate that both surviving projection neurons and local interneurons may become myelinated. It is suggested that the unorthodox myelination of nerve cell somata and dendrites is caused primarily by the massive deafferentation of the nucleus. This indicates a relationship between synaptic input and the process of myelination of the postsynaptic nerve cells.

摘要

慢性(一年)皮质去传入导致猫外侧膝状体(LGN)中出现有髓神经细胞体和树突状突起。观察到所有大小神经细胞体的4%被致密的髓鞘部分或完全覆盖。树突的髓鞘形成局限于突起的最近端部分。将有髓细胞体和树突的精细结构特征与完整LGN的特征进行比较表明,存活的投射神经元和局部中间神经元都可能发生髓鞘形成。有人提出,神经细胞体和树突的非传统髓鞘形成主要是由该核的大量去传入引起的。这表明突触输入与突触后神经细胞的髓鞘形成过程之间存在关系。

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GABA-containing neuronal processes in normal and cortically deafferented dorsal lateral geniculate nucleus of the cat: an immunogold and quantitative EM study.
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Exp Brain Res. 1991;83(3):562-74. doi: 10.1007/BF00229835.