Madarász M, Somogyi J, Silakov V L, Hámori J
Exp Brain Res. 1983;52(3):363-74. doi: 10.1007/BF00238030.
Residual neurons following chronic surgical disconnection from the cortex were studied by light and electron microscopy in the dorsal Lateral Geniculate Nucleus (LGN) of adult cats. One year after operation the volume of the decorticated LGN had shrunken to approximately half that of the control LGN. The number of nerve cells decreased at the same time, to 13-15% of the control, with relatively higher cell loss in A and A1 laminae than in lamina C. The Golgi, Golgi-EM and EM analysis of the residual neurons revealed that they contain two distinct nerve cell types. (1) 55% of all surviving neurons were identified as geniculo-cortical relay cells, while (2) 45% of the persisting nerve cells were interneurons. These data suggest that in the normal LGN of adult cat 7% (or more) of all nerve cells are local interneurons. Finally, those factors which might contribute to the unexpected survival of many relay neurons to the axotomy-caused retrograde degeneration, are considered and discussed.
通过光学显微镜和电子显微镜，对成年猫背侧外侧膝状核（LGN）中因慢性手术切断与皮层的连接而残留的神经元进行了研究。术后一年，去皮质LGN的体积缩小至对照LGN的约一半。与此同时，神经细胞数量减少至对照的13%-15%，A层和A1层的细胞损失相对高于C层。对残留神经元的高尔基染色、高尔基-电子显微镜和电子显微镜分析显示，它们包含两种不同的神经细胞类型。（1）所有存活神经元的55%被鉴定为膝状体-皮层中继细胞，而（2）持续存在的神经细胞中有45%是中间神经元。这些数据表明，在成年猫的正常LGN中，所有神经细胞的7%（或更多）是局部中间神经元。最后，对那些可能导致许多中继神经元在轴突切断引起的逆行变性中意外存活的因素进行了考虑和讨论。
