Hansebout R R, van der Jagt R H, Sohal S S, Little J R
J Neurosurg. 1981 Nov;55(5):725-32. doi: 10.3171/jns.1981.55.5.0725.
Experiments were conducted to determine the therapeutic value of subarachnoid perfusion of the traumatized dog spinal cord with the fluorocarbon, Fluosol-DA (20%). Control dogs without lesions, but which had durotomy, subarachnoid catheter placement, and saline irrigation for 4 hours, did not have any residual neurological deficit. A series of 41 dogs underwent an acute spinal cord compression using an epidural balloon inflated to a pressure of 160 mm Hg and maintained for 1 hour. Treatment included durotomy only (11 dogs), durotomy with saline perfusion at room temperature (15 dogs), and durotomy with oxygenated Fluosol-DA perfusion at room temperature (15 dogs). The dogs underwent daily grading of neurological status for a 60-day period. Dogs undergoing perfusion of the spinal cord with either saline or oxygenated Fluosol-DA had significantly improved motor recovery (p less than 0.004) compared with dogs undergoing durotomy only. Perfusion with oxygenated Fluosol-DA resulted in significantly better motor recovery (p less than 0.05) than did perfusion with normal saline. Microscopic examination of the traumatized spinal cords failed to reveal a substantial difference between the three groups. However, dogs with better functional results tended to have less destruction of the white matter. Hemorrhagic necrosis of the central gray matter was consistently observed in all traumatized spinal cords.
进行了实验以确定用氟碳化合物氟索-DA（20%）对创伤性犬脊髓进行蛛网膜下腔灌注的治疗价值。未受伤但进行了硬脑膜切开术、蛛网膜下腔置管和4小时生理盐水冲洗的对照犬没有任何残留神经功能缺损。一系列41只犬使用充有160毫米汞柱压力的硬膜外球囊进行急性脊髓压迫并维持1小时。治疗包括仅进行硬脑膜切开术（11只犬）、在室温下进行硬脑膜切开术并生理盐水灌注（15只犬）以及在室温下进行硬脑膜切开术并充氧氟索-DA灌注（15只犬）。这些犬在60天内每天进行神经状态分级。与仅进行硬脑膜切开术的犬相比，用生理盐水或充氧氟索-DA对脊髓进行灌注的犬运动恢复有显著改善（p小于0.004）。充氧氟索-DA灌注导致的运动恢复明显优于生理盐水灌注（p小于0.05）。对创伤性脊髓的显微镜检查未能揭示三组之间的实质性差异。然而，功能结果较好的犬白质破坏往往较少。在所有创伤性脊髓中均始终观察到中央灰质的出血性坏死。
