Miller J J, Olds-Arroyo L
J Rheumatol. 1981 Sep-Oct;8(5):716-24.
The effects of concentration of PHA-P and time in culture on cells from patients with systemic, polyarticular and pauciarticular juvenile arthritis have been studied. Responses to suboptimal concentrations are depressed at 3 days, particularly of systemic and polyarticular patients, but normal by 5 days and probably prolonged at 7 days. The responses approach normal with 5 micrograms/ml PHA-P. This delay also occurs in cells from children with cystic fibrosis and acute pneumonia and so is not disease specific. Kinetic studies show a slower recruitment of cells. The delay is corrected by 1 microgram/ml indomethacin. After 7 days, cultures from patients with juvenile arthritis have fewer E, heat-stable E, and EAC rosetting cells than do cultures from normal children or children with cystic fibrosis.
研究了植物血凝素-P（PHA-P）浓度和培养时间对全身型、多关节型和少关节型幼年型关节炎患者细胞的影响。对次优浓度的反应在3天时受到抑制，全身型和多关节型患者尤其如此，但在5天时恢复正常，7天时可能延长。用5微克/毫升PHA-P时反应接近正常。这种延迟也出现在囊性纤维化和急性肺炎患儿的细胞中，因此并非疾病特异性的。动力学研究表明细胞募集较慢。1微克/毫升消炎痛可纠正这种延迟。7天后，幼年型关节炎患者的培养物中E、热稳定E和EAC花环形成细胞比正常儿童或囊性纤维化儿童的培养物中少。
