Miller J J, Olds L C
Children's Hospital at Stanford, Palo Alto, CA 94304.
J Rheumatol. 1987 Aug;14(4):736-9.
Interleukin-2 (IL-2) production by cells from children with various forms of arthritis, systemic lupus erythematosus, and cystic fibrosis was compared. In all cases more IL-2 was detectable at 24 than at 48 h and production was increased by addition of indomethacin. Cultures from children with either active lupus or the pneumonia of cystic fibrosis produced very little IL-2, but cultures from children with arthritis produced apparently normal amounts. We conclude that depressed production of IL-2 in juvenile arthritis may be a secondary epiphenomenon and not a primary immunologic deficit.
对患有各种形式关节炎、系统性红斑狼疮和囊性纤维化的儿童细胞产生白细胞介素-2（IL-2）的情况进行了比较。在所有情况下，24小时时可检测到的IL-2比48小时时更多，并且添加吲哚美辛会增加其产生量。患有活动性狼疮或囊性纤维化肺炎的儿童的培养物产生的IL-2非常少，但患有关节炎的儿童的培养物产生的量显然正常。我们得出结论，青少年关节炎中IL-2产生降低可能是一种继发性附带现象，而非原发性免疫缺陷。
