Sergeev S A, Gribanov G A
Kosm Biol Aviakosm Med. 1981 Nov-Dec;15(6):71-4.
By a modified microthin-layer chromatography in the total lipid spectrum of the cardiac muscle of white rats exposed to acute oxygen deficiency in an altitude chamber was investigated. It was found that the content of total lipids, phospholipids, free cholesterol, free fatty acids and triglycerides decreased during acute hypoxia. The exposure induced changes in the amount of glycerophosphatids whose content diminished significantly. The concentration of phosphatidyl serines and phosphatidyl ethanol amines lowered to a lesser extent while that of sphingomyelins increased. Acute oxygen deficiency accelerates the release of inorganic phosphate from the heart, thus, together with other factors, leading to disorders in the heart energetics. These findings indicate an important role of hypoxic hypoxia in the disturbances of lipid metabolism of the myocardium. This needs to be taken into consideration in the diagnostics and treatment of such states.
通过改良的微薄层色谱法，对在高原舱中暴露于急性缺氧环境的白鼠心肌总脂质谱进行了研究。结果发现，急性缺氧期间总脂质、磷脂、游离胆固醇、游离脂肪酸和甘油三酯的含量降低。暴露导致甘油磷脂数量发生变化，其含量显著减少。磷脂酰丝氨酸和磷脂酰乙醇胺的浓度降低程度较小，而鞘磷脂的浓度增加。急性缺氧加速了心脏中无机磷酸盐的释放，因此与其他因素一起导致心脏能量代谢紊乱。这些发现表明低氧性缺氧在心肌脂质代谢紊乱中起重要作用。在诊断和治疗此类状态时需要考虑到这一点。
