阿托品对离体豚鼠回肠抗胆碱能作用的脱敏作用。
Desensitization to the anticholinergic effects of atropine on isolated guinea pig ileum.
作者信息
Onnen I, Olive G
出版信息
J Pharmacol Methods. 1981 May;5(3):249-53. doi: 10.1016/0160-5402(81)90092-9.
PMID:7311563
Abstract
Guinea pig ileums in Tyrode solution develop a progressive desensitization to the effects of atropine (2-min exposure). This desensitization, followed carefully by a simplified method, is significant from the fourth hr. On the other hand, no desensitization develops to the effects of equilibrium exposure to atropine.
摘要
置于台氏液中的豚鼠回肠对阿托品的作用（2分钟暴露）会产生渐进性脱敏。采用一种简化方法仔细跟踪这种脱敏情况，从第4小时起就很明显。另一方面，对阿托品平衡暴露的作用不会产生脱敏。
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