Hollingsworth M A, Barrowclough J, Evans D L
Mech Ageing Dev. 1981 Sep;17(1):95-106. doi: 10.1016/0047-6374(81)90129-9.
An increase in natural (innate) immunity with age (through 65 weeks) of NBR rats to a syngeneic methylcholanthrene-induced fibrosarcoma (MCA) is described. This increase is characterized by the appearance of spontaneous tumor regressor animals and an increase in the incidence of tumor non-takes by rats 45 weeks of age and older when compared to younger animals. Age-related changes were observed in the in vitro proliferative responses of normal unfractionated and nylon wool fractionated spleen cells to Con A, PHA and irradiated MCA tumor cells. Certain of these different proliferative responses either increased and/or decreases independently at different ages. Relative to normal spleen cell proliferative responses, tumor progressors have decreased proliferative responses and tumor regressors display increased proliferative responses. The significance of this in light of current aging research is discussed.
本文描述了NBR大鼠随着年龄增长（直至65周）对同基因甲基胆蒽诱导的纤维肉瘤（MCA）的天然（固有）免疫增强。这种增强的特征是出现自发肿瘤消退动物，并且与较年轻的动物相比，45周龄及以上的大鼠肿瘤未形成的发生率增加。观察到正常未分级和尼龙毛分级的脾细胞对刀豆蛋白A、植物血凝素和经辐照的MCA肿瘤细胞的体外增殖反应存在与年龄相关的变化。这些不同的增殖反应中的某些在不同年龄独立地增加和/或减少。相对于正常脾细胞增殖反应，肿瘤进展者的增殖反应降低，而肿瘤消退者的增殖反应增加。并根据当前的衰老研究讨论了其意义。
