Melamed E, Lavy S, Siew F, Bentin S, Cooper G
J Neurol Neurosurg Psychiatry. 1978 Oct;41(10):894-9. doi: 10.1136/jnnp.41.10.894.
Measurement of the regional cerebral blood flow (rCBF) by the 133Xenon inhalation method and computerised tomography were performed in 25 patients with presenile and senile dementia. Reduction of rCBF and various degrees of ventricular enlargement and cortical sulcal widening were demonstrated in the majority of demented subjects. However, there was no correlation between rCBF values and the severity of ventricular dilatation or cortical atrophy. These findings suggest that loss of brain substance is not an important factor in the reduction of rCBF in dementia.
对25例早老性和老年性痴呆患者采用氙133吸入法和计算机断层扫描测量局部脑血流量(rCBF)。大多数痴呆患者显示rCBF降低以及不同程度的脑室扩大和脑沟增宽。然而,rCBF值与脑室扩张或皮质萎缩的严重程度之间没有相关性。这些发现表明,脑实质丧失不是痴呆患者rCBF降低的重要因素。