Lavy S, Melamed E, Bentin S, Cooper G, Rinot Y
Ann Neurol. 1978 Nov;4(5):445-50. doi: 10.1002/ana.410040510.
Regional cerebral blood flow (rCBF) was measured by the xenon 133 inhalation method in 20 patients with senile and presenile dementia, and values were compared with flow data obtained in a series of 44 age-matched normal controls. The rCBF was reduced in patients with both presenile and senile dementia, and the degree of decrease exceeded the age-related rCBF decline in normal subjects. Similar rCBF reductions were observed in the left and right cerebral hemispheres and in general were homogeneously distributed in the various areas. The rCBF reductions in normal aging and in dementia may be associated with similar underlying cerebral morphological changes. Our findings suggest that the greater rCBF decreases in dementia compared with the values in age-matched controls may quantitatively reflect more severe pathological alterations in the brains of patients with intellectual deterioration.
采用氙133吸入法对20例老年和老年前期痴呆患者进行了局部脑血流量（rCBF）测量，并将测量值与44例年龄匹配的正常对照者的血流数据进行了比较。老年前期和老年痴呆患者的rCBF均降低，且降低程度超过了正常受试者与年龄相关的rCBF下降幅度。在左右大脑半球均观察到类似的rCBF降低，且总体上在各个区域均匀分布。正常衰老和痴呆患者的rCBF降低可能与类似的潜在脑形态学变化有关。我们的研究结果表明，与年龄匹配的对照组相比，痴呆患者rCBF下降幅度更大，这可能定量反映了智力衰退患者大脑中更严重的病理改变。
