Yamaguchi T, Hatazawa J, Kubota K, Abe Y, Fujiwara T, Matsuzawa T
J Am Geriatr Soc. 1983 Jul;31(7):412-6. doi: 10.1111/j.1532-5415.1983.tb03716.x.
One hundred and two subjects (40 men and 62 women) neither having a history of neurologic deficits nor showing organic lesions on computed tomographic examination of the brain were studied. Ages of the subjects ranged from 26 to 81 years. Regional cerebral blood flow was measured by the xenon-133 inhalation method, and the volume percentage of brain with respect to the cranial cavity (craniocerebral index) was calculated by means of computer programs. Regional cerebral blood flow was computed as the fast component of two-compartmental analysis and as the initial slope index value. The percentage of each subject's craniocerebral index in relation to the standard for subjects with non-atrophied brains (brain volume index) was calculated as the indicator of brain atrophy. Both the mean brain fast component values and the mean brain initial slope index values correlated closely with the brain volume index in the elderly (r = 0.60, r = 0.62; P less than 0.0001 in each correlation coefficient). Low cerebral blood flow values coincided with loss of brain substance in the final stage of age-related brain atrophy, but not in the intermediate stage.
对102名受试者（40名男性和62名女性）进行了研究，这些受试者既没有神经功能缺损病史，脑部计算机断层扫描也未显示器质性病变。受试者年龄在26岁至81岁之间。采用氙-133吸入法测量局部脑血流量，并通过计算机程序计算脑体积相对于颅腔的体积百分比（颅脑指数）。局部脑血流量计算为双室分析的快速成分和初始斜率指数值。计算每个受试者的颅脑指数相对于非萎缩性脑受试者标准（脑体积指数）的百分比，作为脑萎缩的指标。在老年人中，平均脑快速成分值和平均脑初始斜率指数值均与脑体积指数密切相关（r = 0.60，r = 0.62；每个相关系数P均小于0.0001）。低脑血流量值与年龄相关性脑萎缩终末期脑实质丧失相符，但与中期不符。
