Gajdos P, Simon N, Elkharrat D, Goulon M
Nouv Presse Med. 1981 Nov 21;10(42):3469-71.
A cellulose diacetate membrane was tested in 60 plasma exchanges (PE) carried out in 16 patients. Access to the vascular compartment was obtained through one single puncture by inserting a catheter into the femoral vein, the blood circuit being provided with an alternating clamp. The exchange of 2 plasma volumes (72.3 +/- 16 ml/kg) reduced IgG, IgA and IgM concentrations to 30.9 +/- 12.1%, 31.6 +/- 14.5% and 28.3 %/- 15.0% respectively of pre-PE concentrations. Similarly, the C3 and C4 complement fractions and factor B were reduced to 32 +/- 12%, 33 +/- 15% and 36 +/- 16% respectively of pre-PE values. The membrane was used several times in 7 patients; its performance remained the same after 3 consecutive uses. In view of its effectiveness and ease of application, the cellulose diacetate membrane appears to be particularly suitable for plasma exchanges in intensive care units.
在16例患者进行的60次血浆置换（PE）中对醋酸纤维素膜进行了测试。通过将导管插入股静脉经单次穿刺进入血管腔，血液回路配有交替夹。置换2个血浆容量（72.3±16 ml/kg）后，IgG、IgA和IgM浓度分别降至血浆置换前浓度的30.9±12.1%、31.6±14.5%和28.3±15.0%。同样，C3和C4补体成分以及B因子分别降至血浆置换前值的32±12%、33±15%和36±16%。该膜在7例患者中使用了多次；连续使用3次后其性能保持不变。鉴于其有效性和易于应用，醋酸纤维素膜似乎特别适用于重症监护病房的血浆置换。
