Eriksson M, Bolme P, Blennow M
Scand J Infect Dis. 1981;13(3):211-5. doi: 10.3109/inf.1981.13.issue-3.09.
The absorption of erythromycin in infants and children was estimated after the administration of an erythromycin suspension. The subjects were divided into 3 age groups: 0-1 month, 1-6 months and 6 months-6 years. The absorption was lower in infants less than 1 month of age than in the older children. Erythromycin ethylsuccinate and erythromycin stearate were equally well absorbed in the fasting state in subjects 6 months-6 years of age. Administration of the drug at mealtimes considerably increased the absorption of erythromycin ethylsuccinate but had little effect on the absorption of erythromycin stearate. The absorption of erythromycin stearate in the fasting state was much lower than that of erythromycin ethylsuccinate in infants 1-6 months of age. None of the infants given erythromycin ethylsuccinate because of an outbreak of whooping-cough on the neonatal ward showed evidence of liver toxicity, nor did they develop symptoms of whooping-cough.
在给予红霉素混悬液后，评估了婴幼儿对红霉素的吸收情况。受试者被分为3个年龄组：0 - 1个月、1 - 6个月和6个月至6岁。1个月以下婴儿的吸收低于大龄儿童。在6个月至6岁的受试者中，琥乙红霉素和硬脂酸红霉素在禁食状态下吸收情况相同。用餐时给药可显著增加琥乙红霉素的吸收，但对硬脂酸红霉素的吸收影响不大。在1 - 6个月的婴儿中，禁食状态下硬脂酸红霉素的吸收远低于琥乙红霉素。新生儿病房因百日咳暴发而接受琥乙红霉素治疗的婴儿均未出现肝毒性迹象，也未出现百日咳症状。
