Chuinard R G, Dabezies E J, Gould J S, Murphy G A, Matthews R E
South Med J. 1981 Dec;74(12):1481-4. doi: 10.1097/00007611-198112000-00017.
The efficacy of reserpine in relieving the pain of reflex sympathetic dystrophy was tested in 25 patients--21 with upper extremity and four with lower extremity involvement. Injection of the drug relieved the acute signs and symptoms in the upper extremity in 12 of 17 patients. Four patients with quiescent reflex sympathetic dystrophy of upper extremities had prophylactic injection at the time of reconstructive surgery; they had no flare of symptoms. Relief was obtained in the four cases of lower extremity dystrophy. Our patients had no significant side effects. The drug is confined to the extremity by a pneumatic tourniquet as used for intravenous regional anesthesia. After the extremity is exsanguinated and the cuff is inflated, 1 mg of reserpine diluted to 50 ml with normal saline is injected intravenously into the upper extremity. In the lower extremity, 2 mg of reserpine diluted to 100 ml is injected. The tourniquet is removed after 15 minutes. The procedure is safe and can be done in an office setting.
对25例患者进行了利血平缓解反射性交感神经营养不良疼痛疗效的测试，其中21例上肢受累，4例下肢受累。在17例上肢患者中，注射该药缓解了12例患者的急性体征和症状。4例上肢静止性反射性交感神经营养不良患者在重建手术时接受了预防性注射，术后症状未加重。4例下肢营养不良患者症状得到缓解。我们的患者未出现明显副作用。该药通过用于静脉区域麻醉的气动止血带局限于肢体。在肢体放血且袖带充气后，将1mg利血平用生理盐水稀释至50ml，静脉注射到上肢。在下肢，注射2mg利血平并稀释至100ml。15分钟后松开止血带。该操作安全，可在门诊进行。
