特发性膜性肾病（IMN）与HLA - DR 3和MT - 2密切相关，与HLA - B 18无关，且与BfF1无关联。

Strong association of idiopathic membranous nephropathy (IMN) with HLA-DR 3 and MT-2 without involvement of HLA-B 18 and no association to BfF1.

作者信息

Müller G A, Müller C, Liebau G, Kömpf J, Ising H, Wernet P

出版信息

Tissue Antigens. 1981 Mar;17(3):332-7. doi: 10.1111/j.1399-0039.1981.tb00708.x.

DOI:10.1111/j.1399-0039.1981.tb00708.x

Abstract

The present study investigated the distribution of HLA-antigens and Bf alleles in a group of 21 patients suffering from biopsy proven Idiopathic Membranous Nephropathy (IMN). A statistically significant increase of HLA-DR3 (76.2%) was detected in the patient group as well as an increase of MT-2 (86%), which is a new supertypic specificity defined within the 8th International Histocompatibility Workshop 1980. No association between BfF1 and IMN can be deduced from this study. Only the common Bf alleles (BfFF, BfFS, BfSS) were found in the patient group presented here. Also the previously reported association between HLA-B18 and IMN was not corroborated by this study. Not a single IMN-patient typed positive for HLA-B18. Thus the presence of two different HLA-DR-Bf-B linkage groups (HLA-DR3/BfF1/HLA-B18 and HLA-DR3/Bf; all alleles/HLA-B8) may point to at least two different immunological mechanisms underlying IMN.

摘要

本研究调查了21例经活检证实为特发性膜性肾病（IMN）患者的HLA抗原和Bf等位基因分布情况。在患者组中检测到HLA - DR3（76.2%）有统计学意义的增加，以及MT - 2（86%）增加，MT - 2是在1980年第八届国际组织相容性研讨会上定义的一种新的超型特异性。本研究无法推断出BfF1与IMN之间存在关联。在本研究的患者组中仅发现了常见的Bf等位基因（BfFF、BfFS、BfSS）。此外，本研究也未证实先前报道的HLA - B18与IMN之间的关联。没有一例IMN患者的HLA - B18分型呈阳性。因此，两种不同的HLA - DR - Bf - B连锁组（HLA - DR3/BfF1/HLA - B18和HLA - DR3/Bf；所有等位基因/HLA - B8）的存在可能表明IMN至少存在两种不同的免疫机制。