甲氨蝶呤在白血病细胞中的药代动力学：剂量和注射方式的影响 - Suppr

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Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.

作者信息

Weissbrod J M, Jain R K, Sirotnak F M

出版信息

J Pharmacokinet Biopharm. 1978 Dec;6(6):487-503. doi: 10.1007/BF01062105.

DOI:10.1007/BF01062105

PMID:731413

Abstract

摘要

相似文献

Pharmacokinetics of methotrexate in leukemia cells: effect of dose and mode of injection.甲氨蝶呤在白血病细胞中的药代动力学：剂量和注射方式的影响

J Pharmacokinet Biopharm. 1978 Dec;6(6):487-503. doi: 10.1007/BF01062105.

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.小鼠肿瘤模型中高剂量甲氨蝶呤后的组织药代动力学、DNA合成抑制及肿瘤细胞杀伤

Cancer Res. 1976 Dec;36(12):4672-8.

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.L1210白血病治疗期间细胞通透性差异及甲氨蝶呤选择性活性的基础。

Cancer Res. 1973 Jun;33(6):1290-4.

Reversibility of high-affinity binding of methotrexate in L1210 murine leukemia cells.

Cancer Res. 1978 Sep;38(9):2866-70.

Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture.

Mol Pharmacol. 1980 Sep;18(2):274-80.

Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.在小鼠白血病模型中，大剂量甲氨蝶呤后亚叶酸钙的生化和药代动力学效应。

Cancer Res. 1976 Dec;36(12):4679-86.

Binding properties of the 5-methyltetrahydrofolate/methotrexate transport system in L1210 cells.L1210细胞中5-甲基四氢叶酸/甲氨蝶呤转运系统的结合特性

Arch Biochem Biophys. 1980 Jun;202(1):144-9. doi: 10.1016/0003-9861(80)90416-6.

The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.抗叶酸药物对L1210白血病细胞DNA合成抑制作用的细胞内浓度依赖性

Cancer Res. 1974 Dec;34(12):332-40.

A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.用于研究异质交换扩散的模型系统：甲氨蝶呤与叶酸在L1210白血病细胞和艾氏腹水瘤细胞中的相互作用

Biochim Biophys Acta. 1971 Jun 1;233(3):624-34. doi: 10.1016/0005-2736(71)90162-3.

Intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in L1210 cells.

Biochem Biophys Res Commun. 1982 Jan 29;104(2):474-82. doi: 10.1016/0006-291x(82)90661-1.

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Nat Rev Cancer. 2025 May;25(5):324-340. doi: 10.1038/s41568-025-00796-w. Epub 2025 Feb 19.

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.重塑肿瘤物理微环境以改善药物递送与疗效：从数学建模到实验台再到临床应用

Trends Cancer. 2018 Apr;4(4):292-319. doi: 10.1016/j.trecan.2018.02.005. Epub 2018 Mar 13.

The pharmacokinetic/pharmacodynamic pipeline: translating anticancer drug pharmacology to the clinic.药代动力学/药效学研究流水线：将抗癌药物药理学转化为临床实践

AAPS J. 2011 Mar;13(1):111-20. doi: 10.1208/s12248-011-9253-1. Epub 2011 Jan 19.

Pharmacokinetics of methotrexate in solid tumors.甲氨蝶呤在实体瘤中的药代动力学。

J Pharmacokinet Biopharm. 1979 Apr;7(2):181-94. doi: 10.1007/BF01059737.

Targeting anticancer drugs to the brain: II. Physiological pharmacokinetic model of oxantrazole following intraarterial administration to rat glioma-2 (RG-2) bearing rats.将抗癌药物靶向输送至脑部：II. 奥沙曲唑经动脉注射给予荷大鼠神经胶质瘤-2（RG-2）大鼠后的生理药代动力学模型

J Pharmacokinet Biopharm. 1993 Oct;21(5):575-92. doi: 10.1007/BF01059115.

本文引用的文献

Effects of selected cancer chemotherapeutic drugs on the survival times of mice with L-1210 leukemia: relative responses of antimetabolite resistant strains.

Cancer Res. 1962 Jan;22(1)Pt 2:57-72.

Energy metabolism, body size, and problems of scaling.

Fed Proc. 1970 Jul-Aug;29(4):1524-32.

Preliminary model for methotrexate pharmacokinetics.甲氨蝶呤药代动力学的初步模型

J Pharm Sci. 1970 Feb;59(2):149-54. doi: 10.1002/jps.2600590203.

Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.叶酸类似物甲氨蝶呤在L1210白血病细胞中的载体介导转运

J Biol Chem. 1968 Oct 10;243(19):5007-17.

Methotrexate pharmacokinetics.甲氨蝶呤的药代动力学。

J Pharm Sci. 1971 Aug;60(8):1128-33. doi: 10.1002/jps.2600600803.

The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.甲氨蝶呤在小鼠小肠中的细胞毒性与叶酸还原酶抑制及DNA合成抑制的关系。

Cancer Res. 1971 Dec;31(12):2037-46.

Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells.L1210白血病细胞中叶酸-抗叶酸转运机制的立体化学特征。

Cancer Res. 1974 Feb;34(2):371-7.

Bi-directional permeability of the human peritoneum to middle molecules.人腹膜对中分子物质的双向通透性。

Proc Eur Dial Transplant Assoc. 1973;10(0):247-62.

Cancer Res. 1973 Jun;33(6):1290-4.

Transport and binding of methotrexate in vivo.

J Pharm Sci. 1973 Jun;62(6):882-90. doi: 10.1002/jps.2600620603.

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