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[单层培养中髓样细胞与基质成纤维细胞的相互作用]

[Interaction of myeloid cells with stromal fibroblasts in monolayer cultures].

作者信息

Kuznetsov S A, Luriia E A, Genkina E N

出版信息

Tsitologiia. 1981 Oct;23(10):1149-53.

PMID:7314247
Abstract

Stromal fibroblasts of bone marrow, spleen and thymus origin as well as fibroblasts of peritoneal fluid origin are shown to have no difference in the ability to bind morphologically distinguishable granuloid cells in monolayer cultures. On the contrary, thymus fibroblast colonies encourage the development of myeloid cell plaques (which are formed by bone marrow hemopoietic precursor cells) a great deal stronger than do bone marrow and peritoneal fluid fibroblast colonies. It means that their different origin may be revealed when they interact with hemopoietic precursor cells but not with differentiated myeloid cells.

摘要

骨髓、脾脏和胸腺来源的基质成纤维细胞以及腹腔液来源的成纤维细胞,在单层培养中与形态上可区分的粒细胞结合的能力并无差异。相反,胸腺成纤维细胞集落比骨髓和腹腔液成纤维细胞集落更能有力地促进髓样细胞斑块(由骨髓造血前体细胞形成)的发育。这意味着当它们与造血前体细胞而非分化的髓样细胞相互作用时,可能会揭示出它们不同的起源。

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