Scholz D, Schwille P O, Herzog T, Sigel A
Urol Res. 1981;9(6):263-9. doi: 10.1007/BF00257775.
The effect on the urinary excretion of calcium of an oral cation exchange resin without phosphorus was studied in healthy control subjects and patients with recurrent calcium lithiasis under out-patient conditions. An immediate reduction of intestinal calcium absorption and urinary calcium excretion was found in five control subjects and in one patient after ingestion of resin, whereas calcium excretion remained unchanged in all other patients during long-term treatment. In addition, signs of mild transitory hyperparathyroidism together with an increase in intestinal calcium transport were observed during treatment. It is suggested that intraluminal binding of calcium ions to the resin leads to substantial changes in calcium metabolism with the result that urinary calcium excretion returns to pre-treatment values.
在门诊条件下，对健康对照受试者和复发性钙结石患者研究了不含磷的口服阳离子交换树脂对尿钙排泄的影响。在摄入树脂后，5名对照受试者和1名患者的肠道钙吸收和尿钙排泄立即减少，而在所有其他患者的长期治疗期间，钙排泄保持不变。此外，在治疗期间观察到轻度短暂性甲状旁腺功能亢进的体征以及肠道钙转运增加。提示钙离子在肠腔内与树脂结合导致钙代谢发生实质性变化，结果尿钙排泄恢复到治疗前水平。
