Rugendorff E W, Schneider H J
Urology. 1983 Aug;22(2):143-50. doi: 10.1016/0090-4295(83)90496-x.
The efficacy of the cation exchange preparation, Campanyl, was studied in animal experiments and also in patients with absorptive hypercalciuria suffering from recurrent calcium stones, both in short-term studies on several treatment groups and with long-term maintenance dosage. In a dose of 15 Gm daily, taken with the main meal, the preparation was well tolerated and no serious side effects occurred. The frequency of stone passage, compared with that in the pretreatment period, was reduced by more than half, and urinary calcium excretion was considerably reduced. Litholysis was not observed. Campanyl is considered to be especially useful in patients with hyperabsorptive hypercalciuria. Dosage should be adjusted individually according to urinary calcium concentration.
在动物实验以及患有复发性钙结石的吸收性高钙尿症患者中，对阳离子交换制剂坎帕尼尔（Campanyl）的疗效进行了研究，包括在几个治疗组的短期研究以及长期维持剂量研究中。该制剂每日剂量为15克，与主餐同服，耐受性良好，未出现严重副作用。与治疗前期相比，排石频率降低了一半以上，尿钙排泄量也显著减少。未观察到溶石现象。坎帕尼尔被认为对吸收性高钙尿症患者特别有用。应根据尿钙浓度个体化调整剂量。
