Rugendorff E W, Schneider H J, Gundlach G, Behrendt W A, Kuhn D, Gundlach D
Urologe A. 1977 Jul;16(4):197-203.
The efficacy of the cation exchange preparation Campanyl (T1286) was tested in the treatment and metaphylaxis of calcium-containing urinary calculi. For this purpose, in vitro experiments, animal exeriments, orienting clinical studies in 79 patients, and a long term clinical trial in 42 patients over 12 months were undertaken; 22 of the latter patients are also still being treated with the cation exchange preparation, the observation period for 15 patients being 3 1/2 years and 2 1/2 years for 7 patients. As a result of these studies a lowering of the medium calcium excretion and a reduction of calculus discharge by more than half was achieved in the patients being treated with the cation exchanger, without restriction of calcium in the diet. There was not yet seen litholysis. Serious side effects or an influence on the serum electrolytes was not recorded with Campanyl (T1286).
对阳离子交换制剂坎帕尼尔（T1286）治疗和预防含钙尿路结石的疗效进行了测试。为此，进行了体外实验、动物实验、针对79名患者的定向临床研究以及针对42名患者进行的为期12个月的长期临床试验；后一组患者中有22名仍在接受阳离子交换制剂治疗，15名患者的观察期为3.5年，7名患者为2.5年。这些研究的结果是，在用阳离子交换剂治疗的患者中，实现了尿钙排泄量降低，结石排出量减少一半以上，且饮食中不限制钙的摄入。尚未观察到结石溶解。未记录到坎帕尼尔（T1286）有严重副作用或对血清电解质有影响。
