Olthoff K H, Wustmann U
Z Gesamte Inn Med. 1981 Sep 15;36(18):644-9.
In order to prove the efficacy of the long-term nitrate pentaerythrityltetranitrate (PETN; Pentalong) in latent and stress heart insufficiency (causes ischaemic heart disease and/or hypertension) we examined 18 patients with this vasodilator with monotherapy as well as with digoxin combinations. Under PETN the symptoms of the clinical degree of severity could be clearly improved. Before and after stress the tension index showed a significant increase in the region of sufficiency. The sums of stress and recreation pulse and the mean arterial pressure proved a trend to decrease. The load tolerance on the bicycle ergometer was improved. Under the additional therapy with the fully effective dose of digoxin (dilanacin) with regard to the symptoms, load tolerance and partly also to pulse sums a deterioration of the parameters could be recognized in comparison to the PETN-monotherapy; only the combination with the half digoxin saturation does yielded more favourable results of the pulse sums. Apparently the treatment of patients with latent and stress heart insufficiency with long-term nitrates is an alternative to the therapy with glycosides and is even possibly superior to this.
为了证明长效硝酸戊四醇酯（PETN；Pentalong）对潜在性和应激性心脏功能不全（由缺血性心脏病和/或高血压引起）的疗效，我们使用这种血管扩张剂对18例患者进行了单药治疗以及与地高辛联合治疗的研究。使用PETN后，临床严重程度的症状可明显改善。应激前后，充足区域的张力指数显著增加。应激和恢复脉搏总和以及平均动脉压呈下降趋势。自行车测力计上的负荷耐受性得到改善。与PETN单药治疗相比，在使用全效剂量地高辛（狄拉嗪）进行附加治疗时，在症状、负荷耐受性方面，部分在脉搏总和方面，可发现参数恶化；只有与半量地高辛饱和剂量联合使用时，脉搏总和才产生更有利的结果。显然，用长效硝酸盐治疗潜在性和应激性心脏功能不全患者是糖苷类治疗的一种替代方法，甚至可能优于糖苷类治疗。
