Mattern H J
Med Klin. 1981 Feb 27;76(5):135-7.
The results of this study with 102 patients, suffering from cardiac insufficiency and coronary heart disease are that a fixed combination of digoxin with nitrate-compositions is not convenient. In 45 cases the digoxin dose had to be altered, partly even several times, whilst only in 23 patients an alteration of the dosage of the nitrate compositions had to be done, independently from the digoxin dose.
这项针对102例患有心脏功能不全和冠心病患者的研究结果表明，地高辛与硝酸盐组合物的固定组合并不方便。在45例患者中，地高辛剂量不得不改变，部分患者甚至改变了好几次，而只有23例患者不得不改变硝酸盐组合物的剂量，且与地高辛剂量无关。
