Christensen N O, Nydal R, Frandsen F, Sirag S B, Nansen P
Z Parasitenkd. 1981;65(3):293-8. doi: 10.1007/BF00926723.
Schistosoma sp. induced cross-resistance to a challenge with Fasciola hepatica and Echinostoma revolutum was studied in mice. Primary patent 56-days-old S. intercalatum and S. bovis infections stimulated a statistically significant level of resistance to a challenge with F. hepatica, and primary patent 100-day-old S. bovis infections induced an almost complete resistance to a challenge with E. revolutum. Primary single-sex S. mansoni infections, either male or female, aged 90 days did not stimulate any resistance to a challenge with E. revolutum. A primary infection with S. mansoni aged 70 days induced a marked reduction (94.1--100%) in the E. revolutum worm recovery already 2 h post-challenge as compared with that of the E. revolutum challenge control group and complete elimination of the echinostome worm population in S. mansoni infected mice had taken place 24 h after challenge. E. revolutum worm populations established in mice harbouring newly patent 36-day-old S. mansoni infections persisted unchanged for a period of at least 33 days into the patent period of the schistosome infection in spite of development of a complete resistance to a challenge with E. revolutum metacercariae during this period.
在小鼠中研究了血吸虫属诱导的对肝片吸虫和卷棘口吸虫攻击的交叉抗性。56日龄的间插血吸虫和牛血吸虫初次显性感染刺激了对肝片吸虫攻击的统计学显著水平的抗性，100日龄的牛血吸虫初次显性感染诱导了对卷棘口吸虫攻击的几乎完全抗性。90日龄的曼氏血吸虫单性初次感染，无论是雄性还是雌性，都没有刺激对卷棘口吸虫攻击的任何抗性。70日龄的曼氏血吸虫初次感染在攻击后2小时就使卷棘口吸虫的虫体回收率显著降低（94.1%-100%），与卷棘口吸虫攻击对照组相比，并且在攻击后24小时，曼氏血吸虫感染小鼠中的棘口吸虫虫体种群已被完全清除。尽管在此期间对卷棘口吸虫尾蚴攻击已产生完全抗性，但在新显性感染36日龄曼氏血吸虫的小鼠中建立的卷棘口吸虫虫体种群在血吸虫感染的显性期至少持续33天保持不变。
