Christensen N O, Furu P, Kurtzhals J, Odaibo A
Danish Bilharziasis Laboratory, Charlottenlund, Denmark.
Parasitol Res. 1988;74(6):544-51. doi: 10.1007/BF00531632.
Primary infections with Plasmodium yoelii and Echinostoma revolutum in the mouse induced a significant increase in the heterologous Schistosoma mansoni challenge worm establishment, whereas S. mansoni worm establishment remained unaffected by primary infections with Trypanosoma brucei and Babesia microti. Concurrent infection in the mouse with P. yoelii or T. brucei, but not with B. microti, blocked the resistance to homologous E. revolutum challenge infection, and primary P. yoelii and T. brucei infections and corticosteroid treatment made naive, innately resistant mice susceptible to E. revolutum infection. Innate resistance to infection with E. revolutum, the pattern of expulsion of low-level E. revolutum infections, and resistance to homologous S. mansoni challenge infection remained unaffected by concurrent B. microti infection. Primary, heavy E. revolutum infections in the mouse resulted in the enhancement of subsequent infection with B. microti, whereas primary infection with S. mansoni suppressed subsequent B. microti infection in some but not all experiments. In a single experiment, P. yoelii infection was suppressed markedly by primary S. mansoni infection, whereas the enhancement of P. yoelii infection in concurrently E. revolutum-infected mice was seen in only one of the several experiments conducted. However, no interference with resistance to homologous B. microti and P. yoelii challenge infection was induced by concurrent infection with S. mansoni and E. revolutum. We suggest that the synergistic interactions demonstrated between protozoans and helminths in concurrent experimental infection in the mouse are induced by immunosuppression.
小鼠感染约氏疟原虫和卷棘口吸虫的原发性感染会导致曼氏血吸虫异源攻击感染的虫体建立显著增加,而曼氏血吸虫的虫体建立不受布氏锥虫和微小巴贝斯虫原发性感染的影响。小鼠同时感染约氏疟原虫或布氏锥虫,但不感染微小巴贝斯虫,会阻断对同源卷棘口吸虫攻击感染的抵抗力,原发性约氏疟原虫和布氏锥虫感染以及皮质类固醇治疗会使原本天生具有抵抗力的小鼠易受卷棘口吸虫感染。对卷棘口吸虫感染的天生抵抗力、低水平卷棘口吸虫感染的排出模式以及对同源曼氏血吸虫攻击感染的抵抗力不受同时感染微小巴贝斯虫的影响。小鼠原发性、重度卷棘口吸虫感染会导致随后微小巴贝斯虫感染增强,而在一些但并非所有实验中,原发性曼氏血吸虫感染会抑制随后的微小巴贝斯虫感染。在一项单一实验中,原发性曼氏血吸虫感染显著抑制了约氏疟原虫感染,而在同时感染卷棘口吸虫的小鼠中约氏疟原虫感染的增强仅在进行的几个实验中的一个实验中出现。然而,同时感染曼氏血吸虫和卷棘口吸虫不会诱导对同源微小巴贝斯虫和约氏疟原虫攻击感染的抵抗力受到干扰。我们认为,在小鼠同时进行的实验感染中,原生动物和蠕虫之间表现出的协同相互作用是由免疫抑制诱导的。