Franco M, Nordt F J, Corfield A P, Schauer R
Acta Biol Med Ger. 1981;40(4-5):409-12.
An in vitro assay system was developed to test the propensity of "old" and sialidase-treated rat erythrocytes to be bound and phagocytosed by rat peritoneal macrophages. Cells considered to be old were phagocytosed to a greater degree than those considered to be young. When erythrocytes were treated with immobilized Vibrio cholerae sialidase, higher amounts of sialic acids had to be removed (25--30%) to induce binding and phagocytosis of the cells, than if the cells had been treated with soluble enzyme (9--15%).
开发了一种体外测定系统，以测试“衰老”和经唾液酸酶处理的大鼠红细胞被大鼠腹腔巨噬细胞结合和吞噬的倾向。被认为是衰老的细胞比被认为是年轻的细胞更易被吞噬。当用固定化霍乱弧菌唾液酸酶处理红细胞时，与用可溶性酶处理细胞相比，需要去除更多量的唾液酸（25%-30%）才能诱导细胞的结合和吞噬（9%-15%）。
