视网膜色素变性患者房水和血浆中的氨基酸

Aqueous humour and plasma amino acids in tapeto-retinal degenerations.

作者信息

Ehlers N

出版信息

Acta Ophthalmol (Copenh). 1981 Aug;59(4):576-86. doi: 10.1111/j.1755-3768.1981.tb08345.x.

DOI:10.1111/j.1755-3768.1981.tb08345.x

Abstract

The concentration of 18 amino acids and related compounds has been determined in plasma and aqueous humour in 17 patients with tapeto-retinal degenerations, among them 10 patients with retinitis pigmentosa. When compared with a previously obtained reference series of 40 patients abnormal aqueous concentrations (Caq) were found for taurine, glutamine, glutamic acid, proline, glycine, alpha-ANBA and cystine. As regards the plasma concentrations (Cpl) only glutamic acid and alpha-ANBA showed abnormal values. Several of the substances showing abnormal concentrations are possible neurotransmittors or inhibitors. The results suggest that aqueous humour analysis will be a useful way of studying retinal degenerations.

摘要

已测定了17例视网膜色素变性患者血浆和房水中18种氨基酸及相关化合物的浓度，其中10例为视网膜色素变性患者。与先前获得的40例患者的参考系列相比，发现牛磺酸、谷氨酰胺、谷氨酸、脯氨酸、甘氨酸、α-ANBA和胱氨酸的房水浓度（Caq）异常。至于血浆浓度（Cpl），只有谷氨酸和α-ANBA显示出异常值。几种浓度异常的物质可能是神经递质或抑制剂。结果表明，房水分析将是研究视网膜变性的一种有用方法。