视网膜色素变性患者血小板和血浆中的牛磺酸及其他氨基酸

Taurine and other amino acids of platelets and plasma in retinitis pigmentosa.

作者信息

Airaksinen E M, Oja S S, Marnela K M, Sihvola P

出版信息

Ann Clin Res. 1980 Apr;12(2):52-4.

Abstract

The biochemical cause of human retinitis pigmentosa (RP) is unknown, although in kittens it is related to taurine deficiency. The concentrations of free amino acids were therefore determined in the plasma and platelets of 16 patients with RP and 27 controls. No statistically significant change was found in the plasma, but the concentration of taurine and aspartic acid of platelets calculated per number of platelets were significantly (p < 0.05) lower in RP patients than in controls. This finding correlates with the decreased uptake of taurine by platelets of RP patients and may be connected with the pathogenesis of this disease.

摘要

人类视网膜色素变性（RP）的生化病因尚不清楚，尽管在小猫中它与牛磺酸缺乏有关。因此，测定了16例RP患者和27例对照者血浆和血小板中游离氨基酸的浓度。血浆中未发现统计学上的显著变化，但按血小板数量计算，RP患者血小板中牛磺酸和天冬氨酸的浓度显著低于对照组（p<0.05）。这一发现与RP患者血小板对牛磺酸摄取减少相关，可能与该疾病的发病机制有关。