Airaksinen P J, Mustonen E, Alanko H I
Acta Ophthalmol (Copenh). 1981 Oct;59(5):627-41. doi: 10.1111/j.1755-3768.1981.tb08728.x.
Both small splinter haemorrhages of the optic disc and retinal nerve fibre layer (RNFL) defects have been reported to be the first signs of glaucomatous development before visual field defects. In this study their time- and location-based relationship to each other was investigated by means of repeated optic disc stereophotography of 25 patients who showed a disc haemorrhage but no disc and field involvement in their ocular hypertensive eyes. During a mean follow-up time of 6 years, 8 patients developed glaucomatous damage. Their sequential stereo-photographs showed that disc haemorrhages preceded both development and progression of RNFL defects. Location of a defect was accurately predicted by the haemorrhage. In 4 patients the first visual field defects were detected with routine perimetry only 1 to 2 years after the RNFL defects had been observed. Three patients still show normal fields.
视盘小片状出血和视网膜神经纤维层（RNFL）缺损据报道是青光眼性病变在视野缺损之前的最早迹象。在本研究中，通过对25例眼压升高但视盘无病变且视野未受累的患者进行重复视盘立体照相，研究了它们基于时间和位置的相互关系。在平均6年的随访期内，8例患者发生了青光眼性损害。他们的连续立体照片显示，视盘出血先于RNFL缺损的发生和进展。出血可准确预测缺损的位置。4例患者在观察到RNFL缺损后仅1至2年，通过常规视野检查才检测到最初的视野缺损。3例患者视野仍正常。
