Tornling G, Carlsson S, Unge G, Ljungqvist A
Acta Pathol Microbiol Scand A. 1981 Jul;89(4):309-12. doi: 10.1111/j.1699-0463.1981.tb00226.x.
The size of the myocardial infarction following standardized coronary artery occlusion was studied in rats with myocardial hypertrophy due to increased pressure load (aortic stenosis) and increased volume load (swimming exercise). The infarction was significantly smaller in the latter than in the former group. In normal control rats the infarction was larger than in the swimming-exercised rats and smaller than in the rats with aortic stenosis, but these differences were not statistically significant. The observations support the idea that the myocardial capillary neoformation previously shown to be induced by physical exercise may limit the infarction following coronary artery occlusion, whereas the absence of such a capillary reaction in pressure-induced cardiac hypertrophy renders the myocardium more vulnerable, to damage by a coronary occlusion. The size and distribution of the infarction was highly variable as was the configuration of the infarction in the individual heart. For an accurate determination of the size of the infarction, serial sectioning of the whole heart is necessary, with a distance between the sections examined not exceeding 0.5 mm.
在因压力负荷增加（主动脉狭窄）和容量负荷增加（游泳锻炼）导致心肌肥大的大鼠中，研究了标准化冠状动脉闭塞后心肌梗死的大小。后者的梗死面积明显小于前者。在正常对照大鼠中，梗死面积大于游泳锻炼的大鼠，小于主动脉狭窄的大鼠，但这些差异无统计学意义。这些观察结果支持这样一种观点，即先前已证明由体育锻炼诱导的心肌毛细血管新生可能会限制冠状动脉闭塞后的梗死，而压力诱导的心肌肥大中缺乏这种毛细血管反应使心肌更容易受到冠状动脉闭塞的损伤。梗死的大小和分布高度可变，单个心脏中的梗死形态也是如此。为了准确测定梗死面积，必须对整个心脏进行连续切片，所检查切片之间的距离不超过0.5毫米。
