Dishovski H D
Acta Physiol Pharmacol Bulg. 1981;7(2):38-42.
The effect of the phosphorganic compound Neguvon on the contractile responses of guinea-pig ileum to electrical stimulation is studied. At low concentrations this pesticide does not affect significantly the contractions of the segments, while high concentrations block contractile responses. This effect of Neguvon probably has both pre- and postsynaptic character with respect to cholinergic transmission. Washing of the cholinesterase inhibitor fully restores the contractions induced by electrical stimulation, which shows that their inhibition is not directly connected with the inhibition of the cholinesterase activity.
研究了有机磷化合物内吸磷对豚鼠回肠电刺激收缩反应的影响。在低浓度时，这种杀虫剂对肠段收缩无明显影响，而高浓度时则阻断收缩反应。内吸磷的这种作用在胆碱能传递方面可能具有突触前和突触后双重特性。冲洗胆碱酯酶抑制剂可使电刺激诱导的收缩完全恢复，这表明其抑制作用与胆碱酯酶活性的抑制并无直接关联。
