Maksad A K, Lipsky M H, Cha C J, Frayne T C, Clowes G H
Adv Shock Res. 1980;4:41-7.
An isolated level model was used in 25-30 kg pigs to study the uptake and/or release of various energy substrates across the liver and splanchnic bed during trauma and sepsis. This was accomplished by bypassing the hepatic portion of the inferior vena cava (IVC) using a polytetrafluoroethylene (PTFE) (IMPRA, Inc.) graphite-impregnated graft, from above the renal veins to the right atrial junction. The IVC was then ligated between the distal anastomosis and the liver. Sampling was done from inlying catheters placed in the main portal vein, hepatic vena cava, and an artery. Total hepatic blood flow was determined by the dye dilution technique. Our data showed the same pattern of metabolic derangements in both the traumatized and the septic-starved animals, but differed significantly from the normal fed controls. The correlation between glucogenesis and other energy functions of the liver and the proteolysis in skeletal muscle seen in trauma and sepsis is demonstrated. This model is functional and is applicable to the study of various kinds of shock and/or liver failure.
在25 - 30千克的猪身上使用隔离水平模型，以研究创伤和脓毒症期间各种能量底物在肝脏和内脏床的摄取和/或释放情况。这是通过使用聚四氟乙烯（PTFE）（IMPRA公司）石墨浸渍移植物绕过下腔静脉（IVC）的肝段来实现的，从肾静脉上方到右心房交界处。然后在远端吻合口和肝脏之间结扎IVC。从置于主门静脉、肝静脉和一条动脉中的内置导管进行采样。通过染料稀释技术测定总肝血流量。我们的数据显示，创伤和脓毒症饥饿动物的代谢紊乱模式相同，但与正常喂食对照组有显著差异。证实了创伤和脓毒症中肝脏糖异生及其他能量功能与骨骼肌蛋白水解之间的相关性。该模型功能正常，适用于各种休克和/或肝衰竭的研究。
