Barnes H M, Prchal J T, Scott C W
Am J Hematol. 1981 Nov;11(3):305-8. doi: 10.1002/ajh.2830110312.
Idiopathic myelofibrosis (IM) is a myeloproliferative syndrome characterized by anemia, fibrosis of the bone marrow, variable proliferation of megakaryocytes, myelocytic and erythrocytic precursors, and splenomegaly. Extramedullary hematopoiesis can develop in diverse areas. Unlike in chronic granulocytic leukemia, transformation to acute leukemia is uncommon in IM. Transformation to acute leukemia is usually accompanied by the findings of progressive increase in blasts in peripheral blood or bone marrow [1]. We have recently treated a patient with an unusual transition from IM to acute leukemia in whom leukemic transformation began in the central nervous system.
特发性骨髓纤维化（IM）是一种骨髓增殖性综合征，其特征为贫血、骨髓纤维化、巨核细胞、髓细胞和红细胞前体细胞的不同程度增殖以及脾肿大。髓外造血可在不同部位发生。与慢性粒细胞白血病不同，IM转变为急性白血病并不常见。转变为急性白血病通常伴有外周血或骨髓中原始细胞逐渐增加的表现[1]。我们最近治疗了一名从IM异常转变为急性白血病的患者，其白血病转化始于中枢神经系统。
