Gilstrap L C, Leveno K J, Cunningham F G, Whalley P J, Roark M L
Am J Obstet Gynecol. 1981 Nov 15;141(6):709-16. doi: 10.1016/s0002-9378(15)33316-0.
To evaluate the impact of renal infection on pregnancy outcome, we studied a group of pregnant women with asymptomatic renal bacteriuria and another group who had acute pyelonephritis. In 248 women with asymptomatic bacteriuria, infection was localized by the antibody-coated bacteria method. These women were prospectively matched with abacteriuric control subjects and we found no adverse effects of treated renal or bladder infection. Specifically, the number of women with hypertension and anemia in each group was similar, and infants born to these women were comparable regarding perinatal mortality, mean gestational age, and birth weight, as well as indices of maturity. A total of 487 women with acute pyelonephritis were evaluated in a case-control study and observations of the correlation of maternal anemia and pyelonephritis were confirmed. Women with antepartum infection had no increased adverse perinatal outcome; however, in some women with intrapartum infection, pyelonephritis appeared to have initiated premature labor. We concluded that treated renal infection, whether symptomatic or asymptomatic, does not significantly modify pregnancy outcome.
为评估肾脏感染对妊娠结局的影响，我们研究了一组无症状性肾菌尿的孕妇以及另一组患有急性肾盂肾炎的孕妇。在248例无症状菌尿的女性中，通过抗体包被细菌法确定感染部位。这些女性与无菌尿的对照受试者进行前瞻性匹配，我们发现治疗后的肾脏或膀胱感染没有不良影响。具体而言，每组中患有高血压和贫血的女性数量相似，这些女性所生婴儿在围产期死亡率、平均孕周、出生体重以及成熟度指标方面相当。在一项病例对照研究中对总共487例急性肾盂肾炎女性进行了评估，证实了母体贫血与肾盂肾炎相关性的观察结果。产前感染的女性围产期不良结局没有增加；然而，在一些产时感染的女性中，肾盂肾炎似乎引发了早产。我们得出结论，无论有症状还是无症状，治疗后的肾脏感染都不会显著改变妊娠结局。
