Naeye R L
Am J Obstet Gynecol. 1981 Dec 1;141(7):780-7. doi: 10.1016/0002-9378(81)90704-3.
Eleven thousand eighty-two term, singleton pregnancies were analyzed for clues to how different levels of maternal blood pressure affect fetal growth. Birth weights progressively increased with increasing pressures until the hypertensive range was reached when maternal edema and proteinuria were absent. Pressure-associated increases in fetal growth were even more rapid when mothers were edematous, and slower when 2+ or greater proteinuria was present. Birth weights leveled off or decreased when pressures reached the hypertensive range. The pressure threshold at which growth slowed increased from diastolic 75 mm Hg in the lowest maternal pregnancy weight gain category to nearly 100 mm Hg in the highest weight gain category. Decreases in birth weight associated with hypertension were most severe when mothers were thin and had low pregnancy weight gains. Diuretics reduced birth weights in low maternal weight gain pregnancies but not in high weight gain ones.
对11082例足月单胎妊娠进行了分析，以寻找关于母亲不同血压水平如何影响胎儿生长的线索。在无母体水肿和蛋白尿的情况下，出生体重随着血压升高而逐渐增加，直至达到高血压范围。当母亲出现水肿时，与压力相关的胎儿生长增加更为迅速，而当出现2+或更高蛋白尿时则较慢。当血压达到高血压范围时，出生体重趋于平稳或下降。生长减缓的压力阈值从母亲孕期体重增加最少组的舒张压75毫米汞柱增加到最高体重增加组的近100毫米汞柱。当母亲体型瘦且孕期体重增加少时，与高血压相关的出生体重下降最为严重。利尿剂会降低母亲体重增加少的孕期的出生体重，但不会降低母亲体重增加多的孕期的出生体重。
