Finsterer U, Kapser S, Meier W, Reiser-Zimre E, Fischer E, Lühr H G
Anaesthesist. 1981 Nov;30(11):569-74.
Postoperative hypozincemia is a common finding and may be interpreted as ACTH-induced dissociation of zinc from the albumin fraction in plasma. Due to the high protein-bound fraction of zinc in plasma rapidly developing hypozincemia may be caused by dilution of plasma proteins. This may be roughly checked by dividing plasma zinc concentration by plasma protein concentration. By this means we observed that in middle ear surgery and in laparotomies under NLA during anesthesia and surgery there is no evidence for dissociation of zinc from plasma proteins. This probably stress-induced phenomenon was, however, already seen in the first postoperative hour after laparotomies. During anesthesia and surgery we observed a profound increase in renal zinc excretion, the cause of which in unknown.
术后低锌血症是常见现象，可能被解释为促肾上腺皮质激素诱导血浆中锌与白蛋白部分解离。由于血浆中锌与蛋白质结合的部分比例较高，血浆蛋白稀释可能导致低锌血症迅速发展。通过将血浆锌浓度除以血浆蛋白浓度可大致进行检查。通过这种方法我们观察到，在中耳手术以及在神经安定镇痛麻醉（NLA）下进行剖腹手术的麻醉和手术过程中，没有证据表明锌从血浆蛋白中解离。然而，这种可能由应激引起的现象在剖腹手术后的第一个小时就已出现。在麻醉和手术期间，我们观察到肾脏锌排泄显著增加，其原因尚不清楚。
