Bechtel J J, Starr T, Dantzker D R, Bower J S
Am Rev Respir Dis. 1981 Dec;124(6):759-61. doi: 10.1164/arrd.1981.124.6.759.
Methacholine challenge testing was performed in 20 patients with pulmonary sarcoidosis and 13 normal control subjects. Increased methacholine responsiveness was demonstrated in 10 of 20 patients with sarcoidosis. Sarcoidosis patients with increased reactivity differed from those with normal reactivity in that they had more airway obstruction, smaller vital capacities, and lower single breath diffusing capacities for carbon monoxide. Responders tended to be more symptomatic with wheezing and cough and to have a longer duration of disease, although these differences did not reach statistical significance.
对20例肺结节病患者和13名正常对照者进行了乙酰甲胆碱激发试验。20例结节病患者中有10例表现出对乙酰甲胆碱的反应性增加。反应性增加的结节病患者与反应性正常的患者不同，前者有更多的气道阻塞、更小的肺活量和更低的单次呼吸一氧化碳弥散量。反应者往往喘息和咳嗽症状更明显，病程更长，尽管这些差异未达到统计学意义。
