Immelman A, Botha W S, Grïb D
J S Afr Vet Assoc. 1978 Jul;49(2):103-5.
Muscle irritation studies were done in rabbits using 9 different commercial products. Eight products had propylene glycol and 1 had polyvinylpyrrolidone as a vehicle. Macroscopical examination 3,6 and 10 days after intramuscular injection indicated that the irritation caused by the 8 products with propylene glycol as a vehicle were very similar. The product with polyvinylpyrrolidone caused much less damage and healing took place more quickly. Saline used as a control caused no tissue damage.
使用9种不同的市售产品在兔子身上进行了肌肉刺激性研究。8种产品以丙二醇为溶媒，1种产品以聚乙烯吡咯烷酮为溶媒。肌肉注射后3天、6天和10天的宏观检查表明，以丙二醇为溶媒的8种产品引起的刺激非常相似。以聚乙烯吡咯烷酮为溶媒的产品造成的损伤小得多，愈合也更快。用作对照的生理盐水未造成组织损伤。
